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Common antidepressants interact with the opioid pain medication tramadol to make it less effective for pain relief, according to a new study. These findings have important implications for the opioid epidemic, suggesting that some patients suspected of drug-seeking may in fact be under-medicated and just are seeking more effective pain relief. They also could help explain why some people exceed the prescribed dose of tramadol, increasing their risk of addiction.
People exposed to chemical warfare agents (CWAs) often incur chronic damage to their lungs, skin and eyes, for example. They also frequently succumb to depression, anxiety and suicidal thoughts. This is shown by research on survivors from the 1988 gas attacks against Kurdish Halabja in Iraq.
Better care and more research into treatments for people experiencing a first manic episode are urgently needed, according to researchers. The study describes patchy and inconsistent care, widespread failure to detect bipolar disorder early enough, and a lack of guidance on how to treat people experiencing mania for the first time.
Depression is a disorder that often comes along with strong impairments of social functioning. Until recently, researchers assumed that acute episodes of depression also impair empathy, an essential skill for successful social interactions and understanding others. Novel insights show that antidepressant treatment can lead to impaired empathy regarding perception of pain, and not just the state of depression itself.
For some people, medication is an effective part of treatment for depression. However, when considering whether to prescribe antidepressant medication for older adults, healthcare providers must weigh the safety risks these medications pose against the often modest benefits they can provide compared to other options.
A new preclinical study finds that anxiety-like behavior increases when early life adversity combines with high levels of FKBP5 -- a protein capable of modifying hormonal stress response. Moreover, the researchers demonstrate this genetic-early life stress interaction amplifies anxiety by selectively altering signaling of the enzyme AKT in the dorsal hippocampus, a portion of the brain primarily responsible for cognitive functions like learning and memory.
Recordings of neural activity during therapeutic stimulation can be used to predict subsequent changes in brain connectivity, according to a study of epilepsy patients. This approach could inform efforts to improve brain stimulation treatments for depression and other psychiatric disorders.
A simple tweak to the sleeping patterns of \'night owls\' -- people with extreme late sleeping and waking habits -- could lead to significant improvements in sleep/wake timings, improved performance in the mornings, better eating habits and a decrease in depression and stress.
Preliminary results from a new study suggest that sleep disturbances are associated with mental health problems among survivors of a natural disaster even two years after the event.
Addressing the psychological effects of injury can improve health and reduce the negative outcomes of injury. Yet, in a national survey, only 7{493a17b5457788b1fce1f5bb95746c32c65b7d938edf41397829d27dfbb9e1ab} of trauma centers incorporate routine screening for PTSD symptoms.